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KMID : 0903519860290030324
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
1986 Volume.29 No. 3 p.324 ~ p.330
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Effect of Terbufos on the Activity of Acetylcholinesterase in the Chicken
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Abstract
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The responses of brain acetylcholinesterase(Ach-E) and plasma cholinesterase (Ch-E) activities were studied in chickens given oral doses of Terbufos(S-tert-butyl thiomethyl 0,0-diethyl phosphorodithioate), an organophosphorus insecticide. The acute oral LD_(50) of terbufos was 1.82㎎/㎏. The activity of plasma Ch-E was inhibited more rapidly than that of brain Ach.E, whereas recovery of plasma Ch-E activity was more rapid than that of brain Ach-E. Recovery of brain Ach-E and plasma Ch-E was followed the model Y=a+b(log_(10)X). Brain Ach-E activity and plasma Ch-E were inhibited 83% and 94%, respectively, at 60min after administered oral LD_(50).
Brain Ach-E and plasma Ch-E was inhibited in vitro by Terbufos $lt;Terbufos sulfoxide $lt;Terbufos sulfone$lt;Terbufosoxon$lt;Terbufosoxon sulfoxide$lt;Terbufosoxon sulfone.
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